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A phase II, open-label, multicenter trial to investigate the clinical activity and safety of Cabozantinib in combination with avelumab in patients refractory to standard chemotherapy with advanced neuroendocrine neoplasias G3 (NEN G3).

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A phase II, open-label, multicenter trial to investigate the clinical activity and safety of Cabozantinib in combination with avelumab in patients refractory to standard chemotherapy with advanced neuroendocrine neoplasias G3 (NEN G3).

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 28 Jun 2024

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At a glance

  • Drugs Avelumab (Primary) ; Cabozantinib (Primary)
  • Indications Neuroendocrine carcinoma; Neuroendocrine tumours
  • Focus Therapeutic Use
  • Acronyms CaboAveNEC

    • Most Recent Events

    • 05 Mar 2024 Status changed from recruiting to active, no longer recruiting.
    • 24 Oct 2023 Results (n=60 from AVENEC study and n=19 from CABOAVENEC study) assessing the effect of anti-PDL1 therapy with avelumab with highly proliferative neuroendocrine tumors from AVENEC and comparing it with interim analysis of 19 progressive NEN G3 pts from CABOAVENEC presented at the 48th European Society for Medical Oncology Congress
    • 24 Dec 2021 New trial record

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