Trial Profile

A Phase 1 Study to Evaluate the CNS-Penetrant EGFR/ERBB1 Inhibitor ERAS-801 in Patients With Recurrent Glioblastoma (THUNDERBBOLT-1)

Status: Active, no longer recruiting

Phase of Trial: Phase I

Latest Information Update: 13 Feb 2025

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At a glance

Drugs ERAS-801 (Primary)
Indications Glioblastoma
Focus Adverse reactions
Acronyms THUNDERBBOLT-1
Sponsors Erasca

Most Recent Events

10 Feb 2025 Planned primary completion date changed from 31 Jan 2025 to 30 Jun 2025.
17 May 2024 According to an Erasca media release, due to the desire to focus internal resources on developing naporafenib and the RAS-targeting franchise, Erasca is exploring further advancement of ERAS-801 via select investigator-sponsored trial(s).
27 Mar 2024 According to an Erasca media release, initial Phase 1 monotherapy data expected in 2024.

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