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A Prospective, Pilot Study of First-line Osimertinib With or Without Savolitinib in de Novo MET Positive, EGFR-mutant NSCLCs (FLOWERS)

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Trial Profile

A Prospective, Pilot Study of First-line Osimertinib With or Without Savolitinib in de Novo MET Positive, EGFR-mutant NSCLCs (FLOWERS)

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 26 Nov 2024

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At a glance

  • Drugs Osimertinib (Primary) ; Savolitinib (Primary)
  • Indications Non-small cell lung cancer
  • Focus Therapeutic Use
  • Acronyms FLOWERS

    • Most Recent Events

    • 09 Sep 2024 According to Hutchmed media release, data of this study will be presented at the 2024 World Conference on Lung Cancer (WCLC24) in San Diego, USA
    • 03 Sep 2024 According to an AstraZeneca media release, clinical data from this trial will be presented as Poster Session on September 9, 2024 at the IASLC 2024 World Conference on Lung Cancer (WCLC) hosted by the International Association for the Study of Lung Cancer.
    • 03 Sep 2024 According to an AstraZeneca media release, at ESMO a late-breaking, Presidential Symposium presentation for TAGRISSO from the externally sponsored FLOWERS Phase II trial of TAGRISSO with or without savolitinib in patients with EGFRm advanced NSCLC with MET aberrations will evaluate the potential of this novel combination to overcome mechanisms of resistance in the 1st-line setting.

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