Trial Profile

A Phase 1, Randomized, Placebo-Controlled, Double-Blind, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL919 in Healthy Participants

Status: Completed

Phase of Trial: Phase I

Latest Information Update: 18 Aug 2023

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At a glance

14 Aug 2023 Status changed from recruiting to completed.
08 Aug 2023 According to a Denali Therapeutics Inc media release, results presented at the Denali Therapeutics Inc media release.
08 Aug 2023 According to a Denali Therapeutics Inc media release, the companies will discontinue clinical development of DNL919 in Alzheimer's disease based on the totality of clinical data emerging from the single ascending dose Phase 1 study of DNL919 in healthy volunteers and in consideration of the rapidly evolving treatment landscape for Alzheimer's disease whereby an understanding of drug combinations with newly approved therapies will be important.

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