Trial Profile

Multicenter, Open-label, Phase II Study With a Safety Lead-in Part Investigating the Efficacy, Safety and Pharmacokinetics of Encorafenib and Binimetinib Combination in BRAF V600E Mutated Chinese Patients With Metastatic Non-Small Cell Lung Cancer Who Are BRAF- and MEK Inhibitor Treatment-naïve

Status: Active, no longer recruiting

Phase of Trial: Phase II

Latest Information Update: 27 Jun 2025

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At a glance

Drugs Binimetinib (Primary) ; Encorafenib (Primary)
Indications Adenocarcinoma; Carcinoma; Large cell carcinoma; Non-small cell lung cancer; Squamous cell cancer
Focus Adverse reactions; Registrational; Therapeutic Use
Acronyms OCEANII
Sponsors Pierre Fabre

22 Jun 2025 Planned End Date changed from 1 May 2025 to 5 Sep 2026.
21 Oct 2024 New source identified and integrated China Drug Trials (CTR20212961).
25 Oct 2023 Planned End Date changed from 1 Mar 2025 to 1 May 2025.

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