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A Phase I/II, First-in-Human (FIH), Open-Label, Dose Escalation and Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of LM-108 as a Single Agent or in Combination With Anti-PD-1 Antibody in Subjects With Advanced Solid Tumours

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A Phase I/II, First-in-Human (FIH), Open-Label, Dose Escalation and Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of LM-108 as a Single Agent or in Combination With Anti-PD-1 Antibody in Subjects With Advanced Solid Tumours

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 18 Oct 2024

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At a glance

  • Drugs LM-108 (Primary) ; Programmed cell death 1 receptor expression modulators
  • Indications Gastric cancer; Solid tumours
  • Focus Adverse reactions; First in man
  • Sponsors LaNova Medicines Limited

    • Most Recent Events

    • 11 Oct 2024 Planned End Date changed from 1 Jun 2024 to 1 Dec 2024.
    • 11 Oct 2024 Planned primary completion date changed from 1 Mar 2024 to 1 Dec 2024.
    • 04 Jun 2024 Results of pooled analysis (NCT05199753, NCT05255484, and NCT05518045, data cutoff date December 25, 2023, n=48) assessing efficacy and safety of LM-108 in combination with an anti-PD-1 antibody in patients with gastric cancer were presented at the 60th Annual Meeting of the American Society of Clinical Oncology.

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