A PHASE 2, RANDOMIZED, OPEN-LABEL STUDY OF ENCORAFENIB AND CETUXIMAB PLUS PEMBROLIZUMAB VERSUS PEMBROLIZUMAB ALONE IN PARTICIPANTS WITH PREVIOUSLY UNTREATED BRAF V600E-MUTANT, MSI H/DMMR METASTATIC COLORECTAL CANCER
Latest Information Update: 09 Feb 2026
At a glance
- Drugs Cetuximab (Primary) ; Encorafenib (Primary) ; Pembrolizumab (Primary)
- Indications Adenocarcinoma; Carcinoma; Colorectal cancer
- Focus Therapeutic Use
- Acronyms SEAMARK
- Sponsors Pfizer
Most Recent Events
- 04 Feb 2026 Planned primary completion date changed from 12 Apr 2026 to 1 Jun 2026.
- 14 Aug 2025 Planned End Date changed from 28 Mar 2027 to 26 Jan 2027.
- 14 Aug 2025 Planned primary completion date changed from 28 Mar 2026 to 12 Apr 2026.