Trial Profile

This is a Multicenter, Single Arm, Open-label, run-in Phase Ib / Roll-over Phase II Study of Tucatinib in Combination With Alpelisib in Subjects With PIK3CA-mutant HER2-positive Locally Advanced Unresectable or Metastatic Breast Cancer

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 18 Mar 2025

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At a glance

04 Jun 2024 Interim results(As of January 11, 2024, n=6 pts) analyzing tucatinib combined with PI3Ka inhibitor alpelisib in HER2+ PIK3CA-mutated metastatic breast cancer , presented at the 60th Annual Meeting of the American Society of Clinical Oncology
04 Aug 2023 Planned primary completion date changed from 30 Jun 2023 to 30 Aug 2024.
10 Dec 2022 Trial design presented at the 45th Annual San Antonio Breast Cancer Symposium

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