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A Multi-centre, Randomised, Double-blind, Placebo-controlled, Phase 2 Study to Investigate Efficacy, Safety and Tolerability of SLN360 in Participants With Elevated Lipoprotein(a) at High Risk of Atherosclerotic Cardiovascular Disease Events

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Trial Profile

A Multi-centre, Randomised, Double-blind, Placebo-controlled, Phase 2 Study to Investigate Efficacy, Safety and Tolerability of SLN360 in Participants With Elevated Lipoprotein(a) at High Risk of Atherosclerotic Cardiovascular Disease Events

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 28 Jan 2025

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At a glance

  • Drugs Zerlasiran (Primary)
  • Indications Atherosclerosis; Cardiovascular disorders
  • Focus Therapeutic Use
  • Acronyms ALPACAR-360
  • Sponsors Silence Therapeutics

    • Most Recent Events

    • 18 Nov 2024 Results presented in the Silence Therapeutics Media Release.
    • 18 Nov 2024 According to a Silence Therapeutics media release, data from its Phase 2 ALPACAR-360 study of zerlasiran were published during the Late-Breaking Science Session of the American Heart Association (AHA) Scientific Sessions 2024 in Chicago, Illinois, and simultaneously published in the Journal of the American Medical Association (JAMA).
    • 14 Nov 2024 According to a Silence Therapeutics media release, Results from the ALPACAR-360 Phase 2 study of zerlasiran in atherosclerotic cardiovascular disease (ASCVD) patients with high Lp(a) will be presented during the Late-Breaking Science Session of the American Heart Association (AHA) Annual Scientific Sessions in Chicago, Illinois, on Monday, November 18, 2024.

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