A Prospective Observational Sub-Study of the Global Hypophosphatasia Registry to Describe the Potential Risk of Immune-Mediated Loss of Pharmacological Effect of Asfotase Alfa in Participants With Hypophosphatasia
Latest Information Update: 11 Feb 2026
At a glance
- Drugs Asfotase alfa (Primary)
- Indications Hypophosphatasia
- Focus Adverse reactions; Therapeutic Use
- Sponsors Alexion AstraZeneca Rare Disease
Most Recent Events
- 26 Aug 2025 Planned End Date changed from 19 Aug 2029 to 18 Jul 2028.
- 26 Aug 2025 Planned primary completion date changed from 19 Aug 2029 to 18 Jul 2028.
- 19 Aug 2024 Planned number of patients changed from 40 to 30.