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A Phase I/Ib, Open-label Study to Evaluate the Safety, Pharmacokinetics and Clinical Activity of RP7214, a Dihydro-orotate Dehydrogenase (DHODH) Inhibitor, Administered Orally in Combination With Azacitidine in Patients With Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia and Acute Myeloid Leukemia

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Trial Profile

A Phase I/Ib, Open-label Study to Evaluate the Safety, Pharmacokinetics and Clinical Activity of RP7214, a Dihydro-orotate Dehydrogenase (DHODH) Inhibitor, Administered Orally in Combination With Azacitidine in Patients With Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia and Acute Myeloid Leukemia

Status: Withdrawn prior to enrolment
Phase of Trial: Phase I/II

Latest Information Update: 04 Nov 2022

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At a glance

  • Drugs RP 7214 (Primary) ; Azacitidine
  • Indications Acute myeloid leukaemia; Chronic myelomonocytic leukaemia; Myelodysplastic syndromes
  • Focus Adverse reactions
  • Sponsors Rhizen Pharmaceuticals

    • Most Recent Events

    • 27 Oct 2022 Status changed from not yet recruiting to withdrawn prior to enrolment.
    • 17 Aug 2022 Planned initiation date changed from 1 Apr 2022 to 1 Jan 2023.
    • 22 Feb 2022 New trial record

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