Trial Profile

A Phase 2, Multicohort Study of Daratumumab-Based Therapies in Participants With Amyloid Light Chain (AL) Amyloidosis

Status: Recruiting

Phase of Trial: Phase II

Latest Information Update: 29 May 2025

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At a glance

Drugs Bortezomib (Primary) ; Bortezomib (Primary) ; Cyclophosphamide (Primary) ; Cyclophosphamide (Primary) ; Daratumumab (Primary) ; Dexamethasone (Primary) ; Dexamethasone (Primary)
Indications Amyloid light-chain amyloidosis
Focus Adverse reactions; Pharmacokinetics
Acronyms AQUARIUS
Sponsors Janssen Research & Development; Janssen-Cilag

Most Recent Events

23 May 2025 Planned primary completion date changed from 12 Aug 2025 to 3 Mar 2026.
24 Jan 2025 Planned primary completion date changed from 29 Nov 2024 to 12 Aug 2025.
27 Feb 2024 Planned End Date changed from 7 Dec 2027 to 31 Dec 2027.

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