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A Phase 1 Randomized, Subject-Blinded, Active-Controlled, Dose Escalation, Multicenter Trial to Evaluate the Safety, Tolerability, and Immunogenicity of an Investigational Herpes Zoster Vaccine (Z-1018) Compared to Shingrix in Healthy Adult Volunteers Between the Ages of 50 and 69 Years

Trial Profile

A Phase 1 Randomized, Subject-Blinded, Active-Controlled, Dose Escalation, Multicenter Trial to Evaluate the Safety, Tolerability, and Immunogenicity of an Investigational Herpes Zoster Vaccine (Z-1018) Compared to Shingrix in Healthy Adult Volunteers Between the Ages of 50 and 69 Years

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 05 May 2023

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At a glance

  • Drugs Z 1018 (Primary) ; GSK 137173A
  • Indications Varicella zoster virus infections
  • Focus Adverse reactions
  • Sponsors Dynavax Technologies

Most Recent Events

  • 02 May 2023 According to Dynavax media release, data from this trial has been accepted for oral presentation at the National Foundation for Infectious Diseases online 2023 Annual Conference on Vaccinology Research.
  • 09 Jan 2023 According to Dynavax media release, based on these initial data the company intends to advance its shingles vaccine candidate with CpG-1018 adjuvant into a Phase 1/2 study in early 2024 expand on these results and to evaluate various dose levels of Dynavax-manufactured gE protein.
  • 09 Jan 2023 According to Dynavax media release, the company plans to submit an abstract of these results for presentation at an upcoming medical meeting in the first half of 2023.

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