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A Phase 1/2 Trial of the MEK Inhibitor Selumetinib and Bromodomain Inhibitor With Durvalumab (MEDI4736), a PD-L1 Antibody for Sarcomas Including Malignant Peripheral Nerve Sheath Tumors (NF112)

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Trial Profile

A Phase 1/2 Trial of the MEK Inhibitor Selumetinib and Bromodomain Inhibitor With Durvalumab (MEDI4736), a PD-L1 Antibody for Sarcomas Including Malignant Peripheral Nerve Sheath Tumors (NF112)

Status: Not yet recruiting
Phase of Trial: Phase II

Latest Information Update: 13 Jun 2025

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At a glance

  • Drugs Durvalumab (Primary) ; Selumetinib (Primary) ; SRA 515 (Primary)
  • Indications Ewing's sarcoma; Malignant fibrous histiocytoma; Neurofibrosarcoma; Osteosarcoma; Rhabdomyosarcoma; Sarcoma; Soft tissue sarcoma; Synovial sarcoma
  • Focus Adverse reactions; Therapeutic Use

Most Recent Events

  • 08 Jun 2025 Planned End Date changed from 15 Jun 2031 to 15 Dec 2031.
  • 08 Jun 2025 Planned primary completion date changed from 15 Jun 2030 to 15 Dec 2030.
  • 08 Jun 2025 Planned initiation date changed from 15 Jun 2025 to 15 Dec 2025.

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