A Proof-of-concept, Biomarker-driven, Phase-II Clinical Trial to Explore the Activity of Decitabine Repurposing Against Advanced, Refractory, KRAS-dependent Pancreatic Ductal Adenocarcinoma (PDAC):The ORIENTATE Trial

Status: Discontinued

Phase of Trial: Phase II

Latest Information Update: 26 Mar 2025

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At a glance

Drugs Decitabine (Primary)
Indications Adenocarcinoma; Pancreatic ductal carcinoma
Focus Biomarker; Proof of concept; Therapeutic Use
Acronyms ORIENTATE

Most Recent Events

24 Mar 2025 Status changed from recruiting to discontinued.
27 Mar 2023 Planned primary completion date changed from 1 Feb 2023 to 1 Feb 2024.
03 Mar 2022 New trial record

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