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A PHASE 1B/2, OPEN-LABEL, MULTICENTER, DOSE ESCALATION AND DOSE EXPANSION STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, PHARMACODYNAMICS, AND ANTITUMOR ACTIVITY OF PF-07220060 IN COMBINATION WITH PF-07104091 PLUS ENDOCRINE THERAPY IN PARTICIPANTS WITH ADVANCED SOLID TUMORS

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Trial Profile

A PHASE 1B/2, OPEN-LABEL, MULTICENTER, DOSE ESCALATION AND DOSE EXPANSION STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, PHARMACODYNAMICS, AND ANTITUMOR ACTIVITY OF PF-07220060 IN COMBINATION WITH PF-07104091 PLUS ENDOCRINE THERAPY IN PARTICIPANTS WITH ADVANCED SOLID TUMORS

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 27 Sep 2024

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At a glance

  • Drugs Atirmociclib (Primary) ; PF-07104091 (Primary) ; Fulvestrant; Letrozole
  • Indications Advanced breast cancer; HER2 negative breast cancer; HER2 positive breast cancer; Solid tumours
  • Focus Adverse reactions
  • Sponsors Pfizer

    • Most Recent Events

    • 11 Sep 2024 Planned End Date changed from 29 Dec 2026 to 23 Aug 2026.
    • 11 Sep 2024 Planned primary completion date changed from 29 Dec 2026 to 23 Aug 2026.
    • 11 Sep 2024 Status changed from recruiting to active, no longer recruiting.

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