Trial Profile

LOGGIC/FIREFLY-2: A Phase 3, Randomized, International Multicenter Trial of DAY101 Monotherapy Versus Standard of Care Chemotherapy in Patients With Pediatric Low-Grade Glioma Harboring an Activating RAF Alteration Requiring First-Line Systemic Therapy

Status: Active, no longer recruiting

Phase of Trial: Phase III

Latest Information Update: 10 Jul 2026

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At a glance

Drugs Tovorafenib (Primary) ; Tovorafenib (Primary) ; Carboplatin; Vinblastine; Vincristine
Indications Glioma
Focus Registrational; Therapeutic Use
Acronyms FIREFLY-2; LOGGIC
Sponsors Day One Biopharmaceuticals

14 May 2026 Status changed from recruiting to active, no longer recruiting.
08 May 2026 According to a Day One Biopharmaceuticals media release, the patient enrollment has been completed in the trial. And, the preliminary insights from the trial are expected to be available in 2027.
02 Mar 2026 Planned End Date changed from 1 Mar 2030 to 1 Jun 2031.

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