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LOGGIC/FIREFLY-2: A Phase 3, Randomized, International Multicenter Trial of DAY101 Monotherapy Versus Standard of Care Chemotherapy in Patients With Pediatric Low-Grade Glioma Harboring an Activating RAF Alteration Requiring First-Line Systemic Therapy

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LOGGIC/FIREFLY-2: A Phase 3, Randomized, International Multicenter Trial of DAY101 Monotherapy Versus Standard of Care Chemotherapy in Patients With Pediatric Low-Grade Glioma Harboring an Activating RAF Alteration Requiring First-Line Systemic Therapy

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 06 Feb 2025

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At a glance

  • Drugs Tovorafenib (Primary) ; Tovorafenib (Primary) ; Carboplatin; Vinblastine; Vincristine
  • Indications Glioma
  • Focus Registrational; Therapeutic Use
  • Acronyms FIREFLY-2; LOGGIC
  • Sponsors Day One Biopharmaceuticals

    • Most Recent Events

    • 13 Jan 2025 According to a Day One Biopharmaceuticals media release, the company expects to complete enrollment of FIREFLY-2 in the first half of 2026.
    • 06 May 2024 According to a Day One Biopharmaceuticals media release, the company will enroll in the United States, Canada, Europe, Australia and Asia, with more than 90 sites activated.
    • 06 Jun 2023 Trial design presented at the 59th Annual Meeting of the American Society of Clinical Oncology.

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