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A 52-week, Randomized, Double-blind, Double-dummy, Parallel-group, Multi-centre, Non-inferiority Study to Investigate the Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA) Receiving Standard of Care (SoC) Therapy

Trial Profile

A 52-week, Randomized, Double-blind, Double-dummy, Parallel-group, Multi-centre, Non-inferiority Study to Investigate the Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA) Receiving Standard of Care (SoC) Therapy

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 29 May 2025

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At a glance

  • Drugs Depemokimab (Primary) ; Mepolizumab
  • Indications Churg-Strauss syndrome
  • Focus Registrational; Therapeutic Use
  • Acronyms OCEAN
  • Sponsors GlaxoSmithKline; GlaxoSmithKline Research & Development; GSK

Most Recent Events

  • 23 May 2025 Planned End Date changed from 24 Jun 2026 to 24 Nov 2026.
  • 23 May 2025 Planned primary completion date changed from 27 May 2026 to 27 Oct 2026.
  • 27 Mar 2025 Planned End Date changed from 24 Apr 2026 to 24 Jun 2026.

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