A Phase 1, First-in-Human Study of NTX-1088, a Monoclonal Antibody Targeting the Poliovirus Receptor (PVR, CD155), as Monotherapy and Combined With Pembrolizumab, in Patients With Advanced Solid Malignancies
Latest Information Update: 11 Aug 2025
At a glance
- Drugs NTX 1088 (Primary) ; Pembrolizumab (Primary)
- Indications Solid tumours
- Focus Adverse reactions; First in man; Therapeutic Use
- Sponsors Nectin Therapeutics
Most Recent Events
- 29 Jul 2025 Planned End Date changed from 1 Dec 2025 to 1 Dec 2026.
- 29 Jul 2025 Planned primary completion date changed from 1 Jun 2025 to 1 Dec 2025.
- 06 May 2024 According to Nectin Therapeutics media release, Guangzhou-Israel Biotechnology Fund (GIBF) invested in Nectin Therapeutics to continue the development of Nectin's portfolio of novel immuno-oncology products and this global phase I trial.