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A Dose-escalation and Expansion Phase I/IIa Study of XP-102 and XP-102 in Combination With Trametinib in Advanced Solid Tumor Patients With a BRAF V600 Mutation (ENHANCE)

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Trial Profile

A Dose-escalation and Expansion Phase I/IIa Study of XP-102 and XP-102 in Combination With Trametinib in Advanced Solid Tumor Patients With a BRAF V600 Mutation (ENHANCE)

Status: Not yet recruiting
Phase of Trial: Phase I/II

Latest Information Update: 30 Jan 2024

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At a glance

  • Drugs BI-882370 (Primary) ; Trametinib (Primary)
  • Indications Colorectal cancer; Malignant melanoma; Non-small cell lung cancer; Solid tumours; Thyroid cancer
  • Focus Adverse reactions; First in man; Pharmacokinetics
  • Acronyms ENHANCE
  • Sponsors Xynomic Pharmaceuticals

    • Most Recent Events

    • 22 Jan 2024 Planned primary completion date changed from 1 Dec 2024 to 1 Dec 2025.
    • 22 Jan 2024 Planned initiation date changed from 1 Dec 2023 to 1 Dec 2024.
    • 11 Jul 2023 Planned initiation date changed from 1 Dec 2022 to 1 Dec 2023.

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