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Phase 1 Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

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Trial Profile

Phase 1 Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 14 Jan 2025

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At a glance

  • Drugs BCB 276 (Primary)
  • Indications CNS cancer
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Acronyms BrainChild03

    • Most Recent Events

    • 07 Jan 2025 Preliminary safety and efficacy results presented in the BrainChild Bio Media Release.
    • 07 Jan 2025 According to BrainChild Bio media release, company plans to advance BCB-276 in a single pivotal registration trial designed to accelerate the path to submit a Biologics License Application for the treatment of children and young adults with DIPG. This clinical plan is based on alignment with the FDA at a Type B meeting. This potentially accelerated clinical path for BCB-276 is supported by the preliminary data for BCB-276 from this Phase 1 clinical trial conducted by Seattle Children.
    • 18 Mar 2022 New trial record

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