Trial Profile

Open-label Phase II Trial for the Combination of GX-188E HPV DNA Vaccine With GX-I7 or Pembrolizumab OR the Triple Combination of GX-188E HPV DNA Vaccine, GX-I7, and Pembrolizumab in Patients With Advanced, Resectable HPV Type 16 or 18 Positive Head and Neck Cancer (Expanded Cohort)

Status: Active, no longer recruiting

Phase of Trial: Phase II

Latest Information Update: 12 Feb 2026

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At a glance

Drugs Efineptakin alfa (Primary) ; GX 188E (Primary) ; Pembrolizumab (Primary)
Indications Carcinoma; Head and neck cancer; Non-small cell lung cancer; Squamous cell cancer
Focus Therapeutic Use
Acronyms GENUINE

09 Feb 2026 Planned End Date changed from 1 Dec 2025 to 1 Dec 2026.
09 Feb 2026 Planned primary completion date changed from 1 Aug 2025 to 1 Oct 2026.
09 Feb 2026 Status changed from recruiting to active, no longer recruiting.

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