Trial Profile

Phase I/II Clinical Trial of Intrathecal Pemetrexed as First Line Intrathecal Chemotherapy in Patients With Leptomeningeal Metastasis

Status: Completed

Phase of Trial: Phase I/II

Latest Information Update: 12 May 2025

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At a glance

Drugs Cobalamin (Primary) ; Dexamethasone (Primary) ; Folic acid (Primary) ; Pemetrexed (Primary)
Indications Meningeal carcinomatosis; Solid tumours
Focus Adverse reactions

Most Recent Events

04 May 2025 Efficacy endpoint 'Clinical response rate' replaced with safety endpoint 'Incidence of treatment-related adverse events'.
12 Nov 2024 Status changed from active, no longer recruiting to completed.
09 Nov 2023 Planned End Date changed from 1 Sep 2023 to 1 Dec 2023.

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