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Local and Systemic Safety and Tolerability of Ascending Doses of TOP-N53, a Nitric Oxide (NO)-Releasing Phosphodiesterase-5 (PDE5) Inhibitor, Administered Topically, on Wounds in Patients With Digital Ulcers (DU) in Systemic Sclerosis (SSc) in an Open-label, Vehicle-controlled, Phase 2a, Multi-center Clinical Trial

Trial Profile

Local and Systemic Safety and Tolerability of Ascending Doses of TOP-N53, a Nitric Oxide (NO)-Releasing Phosphodiesterase-5 (PDE5) Inhibitor, Administered Topically, on Wounds in Patients With Digital Ulcers (DU) in Systemic Sclerosis (SSc) in an Open-label, Vehicle-controlled, Phase 2a, Multi-center Clinical Trial

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 10 May 2025

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At a glance

  • Drugs TOP N53 (Primary) ; Sildenafil
  • Indications Skin ulcer
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors Topadur Pharma

Most Recent Events

  • 01 May 2025 Status changed from planning to recruiting.
  • 28 Mar 2022 New trial record

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