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Open-label Phase 3 Study of MK-7684A (Coformulation of Vibostolimab With Pembrolizumab) in Combination With Concurrent Chemoradiotherapy Followed by MK-7684A Versus Concurrent Chemoradiotherapy Followed by Durvalumab in Participants With Unresectable, Locally Advanced, Stage III NSCLC

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Trial Profile

Open-label Phase 3 Study of MK-7684A (Coformulation of Vibostolimab With Pembrolizumab) in Combination With Concurrent Chemoradiotherapy Followed by MK-7684A Versus Concurrent Chemoradiotherapy Followed by Durvalumab in Participants With Unresectable, Locally Advanced, Stage III NSCLC

Status: Discontinued
Phase of Trial: Phase III

Latest Information Update: 13 Jan 2025

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At a glance

  • Drugs Carboplatin (Primary) ; Cisplatin (Primary) ; Durvalumab (Primary) ; Etoposide (Primary) ; Paclitaxel (Primary) ; Pembrolizumab+vibostolimab (Primary) ; Pemetrexed (Primary)
  • Indications Non-small cell lung cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms KEYVIBE-006
  • Sponsors Merck Sharp & Dohme

    • Most Recent Events

    • 16 Dec 2024 Status changed from recruiting to discontinued, according to a Merck & Co media release.
    • 16 Dec 2024 According to a Merck & Co media release,considering the totality of data from the Phase 3 KeyVibe studies, including the efficacy outcomes from KeyVibe-003 and KeyVibe-007, the company has decided to discontinue the Phase 3 KeyVibe-006 trial and other vibostolimab studies.
    • 13 Sep 2022 Trial design presented at the 47th European Society for Medical Oncology Congress

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