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A Phase 2/3 Double-Blind, Randomized, Placebo-Controlled Adaptive Design Trial to Evaluate the Efficacy and Safety of Intravenous ACU193 in Early Alzheimer's Disease

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Trial Profile

A Phase 2/3 Double-Blind, Randomized, Placebo-Controlled Adaptive Design Trial to Evaluate the Efficacy and Safety of Intravenous ACU193 in Early Alzheimer's Disease

Status: Active, no longer recruiting
Phase of Trial: Phase II/III

Latest Information Update: 15 Dec 2025

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At a glance

  • Drugs Sabirnetug (Primary)
  • Indications Alzheimer's disease; Cognition disorders; Dementia
  • Focus Registrational; Therapeutic Use
  • Acronyms ALTITUDE-AD
  • Sponsors Acumen Pharmaceuticals

Most Recent Events

  • 02 Dec 2025 According to an Acumen Pharmaceuticals media release, the study tracked 2,362 participants screened across 76 sites, with 542 ultimately enrolled. Out of the 6 recruitment methods used, site databases and physician referrals were most effective for recruiting due to established relationships and pre-screened eligibility.
  • 18 Nov 2025 According to an Acumen Pharmaceuticals media release, the company will present new findings and recruitment strategies for this trial 18th Annual Clinical Trials on Alzheimers Disease (CTAD) on December 1-4, 2025.
  • 17 Nov 2025 According to an Acumen Pharmaceuticals media release, he first participant has been dosed in the open-label extension (OLE) portion of the trial. And, company expects to report topline results from ALTITUDE-AD in late 2026.

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