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SEQUence of Endocrine therapy in advanced Luminal Breast cancer (SEQUEL-Breast): A phase 2 study on fulvestrant beyond progression in combination with alpelisib for PIK3CA-mutated, hormone-receptor positive HER2 negative advanced breast cancer

Trial Profile

SEQUence of Endocrine therapy in advanced Luminal Breast cancer (SEQUEL-Breast): A phase 2 study on fulvestrant beyond progression in combination with alpelisib for PIK3CA-mutated, hormone-receptor positive HER2 negative advanced breast cancer

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 09 Oct 2023

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At a glance

  • Drugs Alpelisib (Primary) ; Fulvestrant (Primary)
  • Indications Adenocarcinoma; Advanced breast cancer; HER2 negative breast cancer
  • Focus Therapeutic Use
  • Acronyms SEQUEL-Breast
  • Most Recent Events

    • 10 Dec 2022 Till June 27, 2023 (n=3) patients were enrolled, as per trial design presented at the 45th Annual San Antonio Breast Cancer Symposium.
    • 10 Dec 2022 Trial design presented at the 45th Annual San Antonio Breast Cancer Symposium.
    • 01 Jun 2022 Planned initiation date changed from 1 May 2022 to 2 Jun 2022.

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