Trial Profile

A Randomized, Placebo-Controlled, Double-Blind, Multi-Center Phase 3 Study of Zipalertinib Plus Adjuvant Chemotherapy Versus Placebo Plus Adjuvant Chemotherapy in Stage IB-IIIA NSCLC Patients With Uncommon EGFR Mutations Following Complete Tumor Resection (REZILIENT4)

Status: Recruiting

Phase of Trial: Phase III

Latest Information Update: 10 Oct 2025

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At a glance

Drugs Carboplatin (Primary) ; Cisplatin (Primary) ; Pemetrexed (Primary) ; Zipalertinib (Primary)
Indications Non-small cell lung cancer
Focus Registrational; Therapeutic Use
Acronyms REZILIENT4
Sponsors Taiho Oncology

25 Sep 2025 Status changed from not yet recruiting to recruiting.
17 Aug 2025 Planned number of patients changed to 360.
16 Apr 2024 According to Cullinan Therapeutics media release, Cullinan Oncology has changed its name to Cullinan Therapeutics.

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