Trial Profile

A Randomized, Placebo-Controlled, Double-Blind, Multi-Center Phase 3 Study of Zipalertinib Plus Adjuvant Chemotherapy Versus Placebo Plus Adjuvant Chemotherapy in Stage IB-IIIA NSCLC Patients With Uncommon EGFR Mutations Following Complete Tumor Resection (REZILIENT4)

Status: Active, no longer recruiting

Phase of Trial: Phase III

Latest Information Update: 07 May 2026

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At a glance

Drugs Carboplatin (Primary) ; Cisplatin (Primary) ; Pemetrexed (Primary) ; Zipalertinib (Primary)
Indications Non-small cell lung cancer
Focus Registrational; Therapeutic Use
Acronyms REZILIENT4
Sponsors Taiho Oncology

23 Apr 2026 Status changed from recruiting to active, no longer recruiting.
31 Oct 2025 Planned initiation date (estimated date of first participant enrollement) changed from 1 Oct 2025 to 1 Nov 2025.
25 Sep 2025 Status changed from not yet recruiting to recruiting.

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