Trial Profile

A Randomized, Placebo-Controlled, Double-Blind, Multi-Center Phase 3 Study of Zipalertinib Plus Adjuvant Chemotherapy Versus Placebo Plus Adjuvant Chemotherapy in Stage IB-IIIA NSCLC Patients With Uncommon EGFR Mutations Following Complete Tumor Resection (REZILIENT4)

Status: Recruiting

Phase of Trial: Phase III

Latest Information Update: 04 Nov 2025

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At a glance

Drugs Carboplatin (Primary) ; Cisplatin (Primary) ; Pemetrexed (Primary) ; Zipalertinib (Primary)
Indications Non-small cell lung cancer
Focus Registrational; Therapeutic Use
Acronyms REZILIENT4
Sponsors Taiho Oncology

31 Oct 2025 Planned initiation date (estimated date of first participant enrollement) changed from 1 Oct 2025 to 1 Nov 2025.
25 Sep 2025 Status changed from not yet recruiting to recruiting.
17 Aug 2025 Planned number of patients changed to 360.

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