Trial Profile

A Phase III, Randomized, Open-Label, Sponsor-Blinded, Multicenter Study of Durvalumab in Combination With Tremelimumab ± Lenvatinib Given Concurrently With TACE Compared to TACE Alone in Patients With Locoregional Hepatocellular Carcinoma (EMERALD-3)

Status: Active, no longer recruiting

Phase of Trial: Phase III

Latest Information Update: 22 Apr 2026

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At a glance

Drugs Durvalumab (Primary) ; Lenvatinib (Primary) ; Tremelimumab (Primary) ; Infliximab; Mycophenolate mofetil
Indications Liver cancer
Focus Registrational; Therapeutic Use
Acronyms EMERALD-3
Sponsors AstraZeneca

02 Apr 2026 Results presented at an AstraZeneca media release.
02 Apr 2026 Primary endpoint has been (Progression Free Survival (PFS) for Arm A vs Arm C) met.
14 Jan 2025 Status changed from recruiting to active, no longer recruiting.

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