Trial Profile

A Randomized, Open-label, Phase II Trial Comparing Neoadjuvant Endocrine Therapy in Combination with Trastuzumab, Pertuzumab +/- the PI3K Inhibitor Inavolisib in Patients with HER2-positive, HR-positive, PIK3CA Mutant Early Breast Cancer-GeparPiPPa

Status: Recruiting

Phase of Trial: Phase II

Latest Information Update: 24 Feb 2025

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At a glance

Drugs Hyaluronidase (Primary) ; Inavolisib (Primary) ; Pertuzumab/trastuzumab (Primary) ; Aromatase inhibitors; Tamoxifen
Indications Early breast cancer; HER2 positive breast cancer; Male breast cancer
Focus Therapeutic Use
Acronyms GeparPiPPa

05 Jan 2023 Planned End Date changed from 1 Jun 2026 to 1 Jan 2027.
05 Jan 2023 Planned primary completion date changed from 1 Mar 2026 to 1 Oct 2026.
05 Jan 2023 Status changed from not yet recruiting to recruiting.

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