Trial Profile

A Phase 1/2 Open-Label, Umbrella Platform Design Study of Investigational Agents With or Without Pembrolizumab (MK-3475) and/or Chemotherapy in Participants With Advanced Esophageal Cancer Previously Exposed to PD-1/PD-L1 Treatment (KEYMAKER-U06): Substudy 06B

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 23 Jul 2025

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At a glance

Drugs Irinotecan (Primary) ; Lenvatinib (Primary) ; MK-4830 (Primary) ; Paclitaxel (Primary) ; Pembrolizumab (Primary)
Indications Carcinoma; Oesophageal cancer; Squamous cell cancer
Focus Adverse reactions; Therapeutic Use
Acronyms KEYMAKER-U06; Substudy 06B
Sponsors Merck Sharp & Dohme

11 Jul 2025 Planned End Date changed from 20 Sep 2028 to 10 Apr 2029.
08 Jan 2024 Planned End Date changed from 31 Dec 2026 to 20 Sep 2028.
08 Jan 2024 Planned primary completion date changed from 17 Feb 2025 to 7 Nov 2026.

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