Trial Profile

A First-in-human Dose-escalation and Expansion Trial With the Antibody-drug Conjugate BYON3521 to Evaluate the Safety, Pharmacokinetics and Efficacy in Patients With c-MET Expressing Locally Advanced or Metastatic Solid Tumours

Status: Completed

Phase of Trial: Phase I

Latest Information Update: 21 Jul 2025

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At a glance

Drugs BYON 3521 (Primary)
Indications Carcinoma; Colorectal cancer; Head and neck cancer; Non-small cell lung cancer; Oesophageal cancer; Pancreatic cancer; Renal cell carcinoma; Solid tumours; Squamous cell cancer; Uveal melanoma
Focus Adverse reactions; First in man
Sponsors Byondis

09 Jul 2025 Status changed from active, no longer recruiting to completed.
06 Jun 2024 Planned End Date changed from 1 Mar 2025 to 1 Jul 2024.
06 Jun 2024 Planned primary completion date changed from 1 Jan 2025 to 1 Jul 2024.

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