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Secondary BRain Metastases Prevention After Isolated Intracranial Progression on Trastuzumab/Pertuzumab or T-DM1 in Patients with ADvanced Human Epidermal Growth Factor Receptor 2+ BrEast Cancer with the Addition of Tucatinib

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Secondary BRain Metastases Prevention After Isolated Intracranial Progression on Trastuzumab/Pertuzumab or T-DM1 in Patients with ADvanced Human Epidermal Growth Factor Receptor 2+ BrEast Cancer with the Addition of Tucatinib

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 17 Mar 2025

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At a glance

  • Drugs Pertuzumab (Primary) ; Trastuzumab (Primary) ; Trastuzumab emtansine (Primary) ; Tucatinib (Primary)
  • Indications Advanced breast cancer; Brain metastases; Carcinoma; HER2 positive breast cancer; Male breast cancer
  • Focus Therapeutic Use
  • Acronyms BRIDGET

    • Most Recent Events

    • 12 Mar 2025 Planned End Date changed from 1 Oct 2027 to 1 Jul 2027.
    • 12 Mar 2025 Planned primary completion date changed from 1 Oct 2026 to 1 Apr 2026.
    • 04 Jun 2024 Planned End Date changed from 1 Apr 2025 to 1 Oct 2027.

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