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A phase 1 trial evaluating MB-109 (combination of MB-101 (IL13R2targeted CAR T cell therapy) and MB-108 (C134 oncolytic virus)) for the treatment of recurrent glioblastoma (rGBM)

Trial Profile

A phase 1 trial evaluating MB-109 (combination of MB-101 (IL13R2targeted CAR T cell therapy) and MB-108 (C134 oncolytic virus)) for the treatment of recurrent glioblastoma (rGBM)

Status: Planning
Phase of Trial: Phase I

Latest Information Update: 13 Mar 2024

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At a glance

  • Drugs MB 109 (Primary)
  • Indications Astrocytoma; Glioblastoma
  • Focus Adverse reactions
  • Sponsors Mustang Bio

Most Recent Events

  • 11 Mar 2024 According to Mustang Bio media release, the company evaluating plans to initiate this trial and request orphan drug designation for GBM, subject to resource allocation, in 2024.
  • 26 Oct 2023 According to Mustang Bio media release, the U.S. Food and Drug Administration (FDA) has accepted the IND application of MB-109 for the treatment of recurrent glioblastoma (GBM) and high-grade astrocytoma.
  • 26 Oct 2023 According to Mustang Bio media release, this trial is expected to begin enrolling patients in 2024.

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