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PNV21-001: A Phase I Study of a Personalized Multi-Peptide Neo-Antigen Vaccine in Breast Cancer, PD1/PD-L1 Inhibitor-Refractory Melanoma, and Pretreated Non-Small Cell Lung Cancer

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Trial Profile

PNV21-001: A Phase I Study of a Personalized Multi-Peptide Neo-Antigen Vaccine in Breast Cancer, PD1/PD-L1 Inhibitor-Refractory Melanoma, and Pretreated Non-Small Cell Lung Cancer

Status: Not yet recruiting
Phase of Trial: Phase I

Latest Information Update: 01 Apr 2026

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At a glance

  • Drugs Nivolumab (Primary) ; Peptide vaccines (Primary) ; Poly ICLC (Primary)
  • Indications Advanced breast cancer; HER2 negative breast cancer; Malignant melanoma
  • Focus Adverse reactions
  • Acronyms PNV21-001

Most Recent Events

  • 12 Mar 2026 Planned End Date changed from 1 Nov 2027 to 1 Nov 2028.
  • 12 Mar 2026 Planned primary completion date changed from 1 Nov 2026 to 1 Nov 2027.
  • 17 Sep 2025 Planned End Date changed from 1 Nov 2026 to 1 Nov 2027.

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