Trial Profile

A Phase 1/2 Open-Label, Ascending Dose, Multicenter Study to Evaluate the Safety and Preliminary Efficacy of AVB-101 Administered by Bilateral Intrathalamic Infusion in Subjects With Frontotemporal Dementia With Progranulin Mutations (FTD-GRN)

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 15 May 2026

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At a glance

13 Apr 2026 Protocol has been amended to include one new arm (Experimental: Cohort 3 (dose 3)) , it has been changed from 2 to 3.
13 Apr 2026 Planned number of patients changed from 38 to 18.
21 Jan 2026 Planned End Date changed from 31 Oct 2030 to 21 Mar 2030.

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