Trial Profile

A PHASE 1, OPEN-LABEL, DOSE ESCALATION AND DOSE EXPANSION STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND ANTI TUMOR ACTIVITY OF PF-07799933 (ARRY-440) AS A SINGLE AGENT AND IN COMBINATION THERAPY IN PARTICIPANTS 16 YEARS AND OLDER WITH ADVANCED SOLID TUMORS WITH BRAF ALTERATIONS

Status: Active, no longer recruiting

Phase of Trial: Phase I

Latest Information Update: 04 Sep 2026

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At a glance

Drugs Binimetinib (Primary) ; Cetuximab (Primary) ; Claturafenib (Primary) ; Fluorouracil; Folinic acid; Midazolam; Oxaliplatin
Indications Brain cancer; Colorectal cancer; Malignant melanoma; Solid tumours
Focus Adverse reactions; First in man; Therapeutic Use
Sponsors Pfizer

01 Sep 2026 Planned End Date changed from 25 Oct 2029 to 31 Aug 2027.
01 Sep 2026 Planned primary completion date changed from 23 Apr 2028 to 31 Aug 2027.
01 Sep 2026 Status changed from recruiting to active, no longer recruiting.

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