Trial Profile

A PHASE 1, OPEN-LABEL, DOSE ESCALATION AND DOSE EXPANSION STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND ANTI TUMOR ACTIVITY OF PF-07799933 (ARRY-440) AS A SINGLE AGENT AND IN COMBINATION THERAPY IN PARTICIPANTS 16 YEARS AND OLDER WITH ADVANCED SOLID TUMORS WITH BRAF ALTERATIONS

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 01 Jan 2026

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At a glance

Drugs Binimetinib (Primary) ; Cetuximab (Primary) ; PF-07799933 (Primary) ; Fluorouracil; Folinic acid; Midazolam; Oxaliplatin
Indications Brain cancer; Colorectal cancer; Malignant melanoma; Solid tumours
Focus Adverse reactions; First in man; Therapeutic Use
Sponsors Pfizer

19 Dec 2025 Planned number of patients changed from 156 to 267.
19 Dec 2025 Planned End Date changed from 28 Sep 2028 to 5 Apr 2030.
19 Dec 2025 Planned primary completion date changed from 28 Mar 2027 to 2 Oct 2028.

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