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A PHASE 1, OPEN-LABEL, DOSE ESCALATION AND DOSE EXPANSION STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND ANTI TUMOR ACTIVITY OF PF-07799933 (ARRY-440) AS A SINGLE AGENT AND IN COMBINATION THERAPY IN PARTICIPANTS 16 YEARS AND OLDER WITH ADVANCED SOLID TUMORS WITH BRAF ALTERATIONS

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A PHASE 1, OPEN-LABEL, DOSE ESCALATION AND DOSE EXPANSION STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND ANTI TUMOR ACTIVITY OF PF-07799933 (ARRY-440) AS A SINGLE AGENT AND IN COMBINATION THERAPY IN PARTICIPANTS 16 YEARS AND OLDER WITH ADVANCED SOLID TUMORS WITH BRAF ALTERATIONS

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 14 Mar 2025

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At a glance

  • Drugs Binimetinib (Primary) ; Cetuximab (Primary) ; PF-07799933 (Primary)
  • Indications Brain cancer; Colorectal cancer; Malignant melanoma; Solid tumours
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Sponsors Pfizer

    • Most Recent Events

    • 12 Mar 2025 Planned End Date changed from 23 Mar 2028 to 9 Aug 2028.
    • 12 Mar 2025 Planned primary completion date changed from 23 Sep 2026 to 6 Feb 2027.
    • 07 Feb 2025 Planned End Date changed from 23 Dec 2027 to 23 Mar 2028.

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