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A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Ascending Doses of REGN5381, an NPR1 Agonist, in Heart Failure Patients With Elevated Pulmonary Capillary Wedge Pressure

Trial Profile

A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Ascending Doses of REGN5381, an NPR1 Agonist, in Heart Failure Patients With Elevated Pulmonary Capillary Wedge Pressure

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 17 Jun 2025

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At a glance

  • Drugs REGN 5381 (Primary)
  • Indications Heart failure
  • Focus Adverse reactions
  • Sponsors Regeneron Pharmaceuticals

Most Recent Events

  • 11 Jun 2025 Status changed from active, no longer recruiting to completed.
  • 21 Feb 2025 Planned End Date changed from 30 Apr 2025 to 6 Jun 2025.
  • 21 Feb 2025 Planned primary completion date changed from 30 Apr 2025 to 6 Jun 2025.

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