Trial Profile

A Phase 1, Multicenter, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of LB1410, A Recombinant Anti-PD-1 and Anti-TIM-3 Humanized Bispecific Antibody for Injection in Patients With Advanced Solid Tumors or Lymphoma Keyplus-001

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 07 Oct 2025

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At a glance

Drugs LB 1410 (Primary)
Indications Adenocarcinoma; Anal cancer; Colorectal cancer; Endometrial cancer; Gastric cancer; Head and neck cancer; Lymphoma; Non-small cell lung cancer; Oesophageal cancer; Ovarian cancer; Small cell lung cancer; Solid tumours; Squamous cell cancer
Focus Adverse reactions; First in man
Acronyms Keyplus-001
Sponsors L and L Biopharma

11 Sep 2025 Planned End Date changed from 11 Mar 2025 to 30 Dec 2028.
11 Sep 2025 Planned primary completion date changed from 30 Dec 2024 to 30 Dec 2026.
31 May 2024 Trial design presented at 60th Annual Meeting of the American Society of Clinical Oncology

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