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An adaptive-design, phase IIa/IIb, open-label, multiple-ascending-dose, dose-finding study to assess the safety, cardiovascular effects, pharmacokinetics and pharmacodynamic profile of 30 mg, 50 mg, and 70 mg of MSP-1014.OX in major depressive disorder (MDD) patients with partial or no response to SSRIs followed by a double-blind, randomised, placebo-controlled, proof-of-concept, efficacy and safety study of the selected dose of MSP-1014.OX in MDD patients with partial or no response to SSRIs

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Trial Profile

An adaptive-design, phase IIa/IIb, open-label, multiple-ascending-dose, dose-finding study to assess the safety, cardiovascular effects, pharmacokinetics and pharmacodynamic profile of 30 mg, 50 mg, and 70 mg of MSP-1014.OX in major depressive disorder (MDD) patients with partial or no response to SSRIs followed by a double-blind, randomised, placebo-controlled, proof-of-concept, efficacy and safety study of the selected dose of MSP-1014.OX in MDD patients with partial or no response to SSRIs

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 03 Aug 2024

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At a glance

  • Drugs MSP 1014 (Primary)
  • Indications Major depressive disorder
  • Focus Adverse reactions; First in man; Proof of concept; Therapeutic Use
  • Sponsors Mindset Pharma

Most Recent Events

  • 28 Jun 2023 Status changed from planning to recruiting.
  • 14 Sep 2022 According to a Mindset Pharma media release, company has received Scientific Advice from the UK Medicines and Healthcare products Regulatory Agency (MHRA) on a range of points to finalize this trial.
  • 19 May 2022 New trial record

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