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A Phase II Multicenter, Open-label, Single-arm Dose Escalation Study of Asciminib Monotherapy in 2nd and 1st Line Chronic Phase - Chronic Myelogenous Leukemia (ASC2ESCALATE)

Trial Profile

A Phase II Multicenter, Open-label, Single-arm Dose Escalation Study of Asciminib Monotherapy in 2nd and 1st Line Chronic Phase - Chronic Myelogenous Leukemia (ASC2ESCALATE)

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 09 Jun 2025

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At a glance

  • Drugs Asciminib (Primary)
  • Indications Chronic myeloid leukaemia
  • Focus Therapeutic Use
  • Acronyms ASC2ESCALATE
  • Sponsors Novartis; Novartis Pharmaceuticals

Most Recent Events

  • 29 May 2025 According to a Sarah Cannon Research Institute media release, interim analysis form this trial will be presented at the ASCO 2025.
  • 25 Nov 2024 According to a Novartis media release, data from this trial will be presented at the 66th American Society of Hematology (ASH) Annual Meeting.
  • 29 Oct 2024 According to a Novartis media release, Scemblix (asciminib) was granted accelerated approval by the US Food and Drug Administration (FDA) for adult patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase (Ph+ CML-CP).

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