Trial Profile

A Phase 1b/2, Open-Label Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 27 Jun 2025

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At a glance

Drugs Amivantamab (Primary) ; Fluorouracil; Folinic acid; Irinotecan; Oxaliplatin
Indications Adenocarcinoma; Colon cancer; Colorectal cancer; Rectal cancer
Focus Adverse reactions; Therapeutic Use
Acronyms OrigAMI-1
Sponsors Janssen Research & Development; Janssen-Cilag

Most Recent Events

22 Jun 2025 Planned End Date changed from 27 Apr 2027 to 21 May 2029.
14 Sep 2024 Results presented in a Johnson & Johnson media release.
14 Sep 2024 According to Janssen media release, new data from this trial presented in a mini-oral presentation at the European Society of Medical Oncology (ESMO) 2024 Congress.

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