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A Phase 1 Study of ASP3082 in Participants With Previously Treated Locally Advanced or Metastatic Solid Tumor Malignancies With KRAS G12D Mutation

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Trial Profile

A Phase 1 Study of ASP3082 in Participants With Previously Treated Locally Advanced or Metastatic Solid Tumor Malignancies With KRAS G12D Mutation

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 22 Jul 2025

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At a glance

  • Drugs ASP 3082 (Primary) ; Carboplatin; Cetuximab; Cisplatin; Docetaxel; Fluorouracil; Folinic acid; Gemcitabine; Irinotecan; Oxaliplatin; Paclitaxel; Pembrolizumab; Pemetrexed
  • Indications Colorectal cancer; Non-small cell lung cancer; Pancreatic cancer; Solid tumours
  • Focus Adverse reactions; First in man
  • Sponsors Astellas Pharma

Most Recent Events

  • 18 May 2025 Planned number of patients changed from 541 to 651.
  • 29 Apr 2025 Number of Arms changed from 7 to 10. Experimental: ASP3082 + Docetaxel - NSCLC, ASP3082 + Pembrolizumab - NSCLC and ASP3082 + (Cisplatin or Carboplatin) and Pemetrexed +/- Pembrolizumab - NSCLC arms along with new drug treatments added to study protocol.
  • 24 Apr 2024 Planned number of patients changed from 356 to 541.

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