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Randomized, Open-Label Study of the Bria-IMT Regimen and Check Point Inhibitor vs Physicians' Choice in Advanced Metastatic Breast Cancer

Trial Profile

Randomized, Open-Label Study of the Bria-IMT Regimen and Check Point Inhibitor vs Physicians' Choice in Advanced Metastatic Breast Cancer

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 23 Nov 2025

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At a glance

  • Drugs SV-BR-1-GM breast cancer vaccine BriaCell Therapeutics (Primary) ; Capecitabine; Carboplatin; Cyclophosphamide; Eribulin; Gemcitabine; Interferon; Retifanlimab; Taxanes; Vinorelbine
  • Indications Advanced breast cancer; HER2 positive breast cancer
  • Focus Adverse reactions; Registrational; Therapeutic Use
  • Acronyms ASTRO-VAC CNS; BRIA-ABC
  • Sponsors BriaCell Therapeutics Corp

Most Recent Events

  • 18 Nov 2025 According to BriaCell Therapeutics media release,data from this trial will be presented at at the 2025 San Antonio Breast Cancer Symposium (SABCS ) taking place from December 9-12, 2025 at Henry B. Gonzalez Convention Center, 900 E. Market Street, San Antonio, Texas.
  • 22 Oct 2025 According to BriaCell Therapeutics Corp media release, company announced that the independent Data Safety Monitoring Board (DSMB) has issued its fourth consecutive positive recommendation following review of safety data from this trial.Following its review, the DSMB raised no safety concerns and recommended that the study continue without modifications.
  • 21 Oct 2025 According to a BriaCell Therapeutics Corp media release, positive results of the pivotal Phase 3 study could result in full approval and marketing authorization for Bria-IMT in MBC patients

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