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An Open-label Multicenter Phase 1b-2 Study of Elacestrant in Combination With Abemaciclib in Women and Men With Brain Metastasis From Estrogen Receptor Positive, HER-2 Negative Breast Cancer

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Trial Profile

An Open-label Multicenter Phase 1b-2 Study of Elacestrant in Combination With Abemaciclib in Women and Men With Brain Metastasis From Estrogen Receptor Positive, HER-2 Negative Breast Cancer

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 09 Mar 2025

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At a glance

  • Drugs Abemaciclib (Primary) ; Elacestrant (Primary)
  • Indications Advanced breast cancer; Brain metastases; HER2 negative breast cancer; Male breast cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms ELECTRA
  • Sponsors Stemline Therapeutics

    • Most Recent Events

    • 25 Nov 2024 According to a Menarini media release, Results to be reported at San Antonio Breast Cancer Symposium (SABCS), December 10-13, 2024, include updated efficacy results from the ELECTRA study which demonstrate favorable progression-free survival (PFS) data.
    • 06 Aug 2024 Planned number of patients changed from 106 to 68.
    • 04 Jun 2024 Results evaluating the safety of elacestrant + abemaciclib and efficacy and safety of the combination in pts with brain metastases since both compounds cross the blood-brain barrier were presented at the 60th Annual Meeting of the American Society of Clinical Oncology.

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