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A Randomized, Double-Blind, Placebo-Controlled Study of Optune (TTFields, 200 kHz) Concomitant With Maintenance TMZ and Pembrolizumab Versus Optune Concomitant With Maintenance TMZ and Placebo for the Treatment of Newly Diagnosed Glioblastoma (EF-41/KEYNOTE D58)

Trial Profile

A Randomized, Double-Blind, Placebo-Controlled Study of Optune (TTFields, 200 kHz) Concomitant With Maintenance TMZ and Pembrolizumab Versus Optune Concomitant With Maintenance TMZ and Placebo for the Treatment of Newly Diagnosed Glioblastoma (EF-41/KEYNOTE D58)

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 24 Jul 2026

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At a glance

  • Drugs Pembrolizumab (Primary) ; Temozolomide
  • Indications Glioblastoma
  • Focus Registrational; Therapeutic Use
  • Acronyms Keynote D58
  • Sponsors Novocure Limited

Most Recent Events

  • 26 Feb 2026 According to Novocure Limited media release, enrollment completion in this study is expected in Q4 2026.
  • 02 May 2024 According to a Novocure media release, in March, the FDA approved the Investigational New Drug (IND) application for this trial.
  • 30 May 2022 New trial record

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