Trial Profile

A Phase 1, Open-Label, Dose Escalation and Expansion, Multicenter Study of Claudin 18.2-Targeted Chimeric Antigen Receptor T-cells in Subjects With Unresectable, Locally Advanced, or Metastatic Gastric, Gastroesophageal Junction (GEJ), Esophageal, or Pancreatic Adenocarcinoma

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 25 Apr 2025

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At a glance

Drugs LCAR-C18S (Primary)
Indications Adenocarcinoma; Gastric cancer; Oesophageal cancer; Pancreatic cancer
Focus Adverse reactions; First in man
Sponsors Legend Biotech USA

22 Apr 2025 Planned End Date changed from 1 Dec 2025 to 1 Dec 2027.
22 Apr 2025 Planned primary completion date changed from 1 Jul 2025 to 1 Dec 2027.
18 Apr 2023 Status changed from not yet recruiting to recruiting.

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