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A Phase 1, Open-Label, Dose Escalation and Expansion, Multicenter Study of Claudin 18.2-Targeted Chimeric Antigen Receptor T-cells in Subjects With Unresectable, Locally Advanced, or Metastatic Gastric, Gastroesophageal Junction (GEJ), Esophageal, or Pancreatic Adenocarcinoma

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A Phase 1, Open-Label, Dose Escalation and Expansion, Multicenter Study of Claudin 18.2-Targeted Chimeric Antigen Receptor T-cells in Subjects With Unresectable, Locally Advanced, or Metastatic Gastric, Gastroesophageal Junction (GEJ), Esophageal, or Pancreatic Adenocarcinoma

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 22 Jul 2024

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At a glance

  • Drugs LCAR-C18S (Primary)
  • Indications Adenocarcinoma; Gastric cancer; Oesophageal cancer; Pancreatic cancer
  • Focus Adverse reactions; First in man
  • Sponsors Legend Biotech USA

    • Most Recent Events

    • 18 Apr 2023 Status changed from not yet recruiting to recruiting.
    • 07 Mar 2023 Planned initiation date changed from 1 Jan 2023 to 1 Apr 2023.
    • 21 Jan 2023 Trial design presented at the 2023 Gastrointestinal Cancers Symposium

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